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Human Estrogen Receptor beta Ligand-binding Domain in Complex with (R)-3-(2-chloro-4-hydroxyphenyl)-2-(4-hydroxyphenyl)propanenitrile

X-ray diffraction
2.08Å resolution
PDB entry 7xvz coloured by chain, front view.
PDB entry 7xvz coloured by chain, side view.
PDB entry 7xvz coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Estrogen receptor beta and Nuclear receptor coactivator 1
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Multimeric state: hetero tetramer
Accessible surface area: 20064.79 Å2
Buried surface area: 3498.33 Å2
Dissociation area: 420.85 Å2
Dissociation energy (ΔGdiss): 2.63 kcal/mol
Dissociation entropy (TΔSdiss): 7.02 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-172402

Macromolecules

Estrogen receptor beta
Chains: A, B
Length: 247 amino acids
Theoretical weight: 27.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92731 (Residues: 261-500; Coverage: 45%)
Gene names: ESR2, ESTRB, NR3A2
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
Estrogen receptor beta in PDB entry 7xvz, assembly 1, front view.
Estrogen receptor beta in PDB entry 7xvz, assembly 1, side view.
Estrogen receptor beta in PDB entry 7xvz, assembly 1, top view.
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Nuclear receptor coactivator 1
Chains: C, D
Length: 13 amino acids
Theoretical weight: 1.39 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15788 (Residues: 630-640; Coverage: 1%)
Gene names: BHLHE74, NCOA1, SRC1
Nuclear receptor coactivator 1 in PDB entry 7xvz, assembly 1, front view.
Nuclear receptor coactivator 1 in PDB entry 7xvz, assembly 1, side view.
Nuclear receptor coactivator 1 in PDB entry 7xvz, assembly 1, top view.
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