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Crystal structure of TMPRSS2 in complex with Camostat

X-ray diffraction
2.39Å resolution
PDB entry 7y0e coloured by chain, front view.
PDB entry 7y0e coloured by chain, side view.
PDB entry 7y0e coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Transmembrane protease serine 2 non-catalytic chain
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Multimeric state: hetero dimer
Accessible surface area: 16402.14 Å2
Buried surface area: 2710.11 Å2
Dissociation area: 1,246.87 Å2
Dissociation energy (ΔGdiss): 7.37 kcal/mol
Dissociation entropy (TΔSdiss): 11.96 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-236242
Assembly 2 (preferred)
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Assembly Name: Transmembrane protease serine 2 non-catalytic chain
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Multimeric state: hetero dimer
Accessible surface area: 15810.36 Å2
Buried surface area: 2981.44 Å2
Dissociation area: 1,236.09 Å2
Dissociation energy (ΔGdiss): 5.96 kcal/mol
Dissociation entropy (TΔSdiss): 11.95 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-236242

Macromolecules

Transmembrane protease serine 2 non-catalytic chain
Chains: A, B
Length: 146 amino acids
Theoretical weight: 16.05 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O15393 (Residues: 109-254; Coverage: 30%)
Gene names: PRSS10, TMPRSS2
Pfam: Scavenger receptor cysteine-rich domain
Transmembrane protease serine 2 non-catalytic chain in PDB entry 7y0e, assembly 2, front view.
Transmembrane protease serine 2 non-catalytic chain in PDB entry 7y0e, assembly 2, side view.
Transmembrane protease serine 2 non-catalytic chain in PDB entry 7y0e, assembly 2, top view.
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Transmembrane protease serine 2 catalytic chain
Chains: C, D
Length: 249 amino acids
Theoretical weight: 27.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O15393 (Residues: 256-492; Coverage: 48%)
Gene names: PRSS10, TMPRSS2
Pfam: Trypsin
Transmembrane protease serine 2 catalytic chain in PDB entry 7y0e, assembly 2, front view.
Transmembrane protease serine 2 catalytic chain in PDB entry 7y0e, assembly 2, side view.
Transmembrane protease serine 2 catalytic chain in PDB entry 7y0e, assembly 2, top view.
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