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3.2 angstrom cryo-EM structure of extracellular region of mouse Basigin-2 in complex with the Fab fragment of antibody 6E7F1

Electron Microscopy
3.23Å resolution
PDB entry 7y1b coloured by chain, front view.
PDB entry 7y1b coloured by chain, side view.
PDB entry 7y1b coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Basigin and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero trimer
Accessible surface area: 25068.66 Å2
Buried surface area: 5307.55 Å2
Dissociation area: 982.64 Å2
Dissociation energy (ΔGdiss): -1.85 kcal/mol
Dissociation entropy (TΔSdiss): 12.11 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-279836

Macromolecules

Basigin
Chain: A
Length: 273 amino acids
Theoretical weight: 29.71 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Isoform 2 of Basigin in PDB entry 7y1b, assembly 1, front view.
Isoform 2 of Basigin in PDB entry 7y1b, assembly 1, side view.
Isoform 2 of Basigin in PDB entry 7y1b, assembly 1, top view.
127320406080100120140160180200220240260
 
100200MAAALLLALAFTLLSGQGACAAAGTIQTSVQEVNSKTQLTCSLNSSGVDIVGHRWMRGGKVLQEDTLPDLHTKYIVDADDRSGEYSCIFLPEPVGRSEINVEGPPRIKVGKKSEHSSEGELAKLVCKSDASYPPITDWFWFKTSDTGEEEAITNSTEANGKYVVVSTPEKSQLTISNLDVNVDPGTYVCNATNAQGTTRETISLRVRSRMAALWPFLGIVAEVLVLVTIIFIYEKRRKPDQTLDEDDPGAAPLKGSGTHMNDKDKNVRQRNAT
UniProt
P18572
Chains
Secondary structure
Flexibility predictions
Sequence conservation
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Heavy chain of 6E7F1
Chain: H
Length: 236 amino acids
Theoretical weight: 25.28 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Heavy chain of 6E7F1 in PDB entry 7y1b, assembly 1, front view.
Heavy chain of 6E7F1 in PDB entry 7y1b, assembly 1, side view.
Heavy chain of 6E7F1 in PDB entry 7y1b, assembly 1, top view.
123620406080100120140160180200220
 
100200MGWSYIILFLVTTATGVHSQVQLQQPGAELVKPGASVNLSCKASGYTFTNYWIHWVKQRPGQGLEWIGMIHPNSGTINYNEKFKTKATLTVDKSSSTAYMQLSSLTSEDSAVYYCARVGTGSLDYWGQGTSVTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPR
Chains
Chain B (auth H)
Secondary structure
Interaction interfaces
Sequence conservation
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Light chain of 6E7F1
Chain: L
Length: 234 amino acids
Theoretical weight: 25.92 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Light chain of 6E7F1 in PDB entry 7y1b, assembly 1, front view.
Light chain of 6E7F1 in PDB entry 7y1b, assembly 1, side view.
Light chain of 6E7F1 in PDB entry 7y1b, assembly 1, top view.
123420406080100120140160180200220
 
100200MVSTSQLLGLLLFWTSASRCDIVMTQSPATLSVTPGDRVSLSCRASQSISDYLHWYQQKSHESPRLLIKYVSQSISGIPSRFSGSGSGSYFTLSIDSVEPEDVGVYYCQNGHRFPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC
Chains
Chain C (auth L)
Secondary structure
Interaction interfaces
Sequence conservation
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