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The cryo-EM structure of human ERAD retro-translocation complex

Electron Microscopy
3.61Å resolution
PDB entry 7y53 coloured by chain, front view.
PDB entry 7y53 coloured by chain, side view.
PDB entry 7y53 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero decamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: VCP-DERL1 AAA ATPase complex
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Multimeric state: hetero decamer
Accessible surface area: 262798.19 Å2
Buried surface area: 52020.59 Å2
Dissociation area: 4,121.98 Å2
Dissociation energy (ΔGdiss): 7.32 kcal/mol
Dissociation entropy (TΔSdiss): 57.29 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-232467

Macromolecules

Derlin-1
Chains: W, X, Y, Z
Length: 226 amino acids
Theoretical weight: 26.48 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9BUN8 (Residues: 1-251; Coverage: 90%)
Gene names: DER1, DERL1, UNQ243/PRO276
Pfam: Der1-like family
Derlin-1 in PDB entry 7y53, assembly 1, front view.
Derlin-1 in PDB entry 7y53, assembly 1, side view.
Derlin-1 in PDB entry 7y53, assembly 1, top view.
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Transitional endoplasmic reticulum ATPase
Chains: A, B, C, D, E, F
Length: 787 amino acids
Theoretical weight: 87.55 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P55072 (Residues: 21-806; Coverage: 98%)
Gene names: HEL-220, HEL-S-70, VCP
Pfam:
Transitional endoplasmic reticulum ATPase in PDB entry 7y53, assembly 1, front view.
Transitional endoplasmic reticulum ATPase in PDB entry 7y53, assembly 1, side view.
Transitional endoplasmic reticulum ATPase in PDB entry 7y53, assembly 1, top view.
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