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SARS-CoV-2 S trimer in complex with 1F Fab

Electron Microscopy
4.8Å resolution
PDB entry 7y7j coloured by chain, front view.
PDB entry 7y7j coloured by chain, side view.
PDB entry 7y7j coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: SARS-CoV-2 post-fusion S2 Spike complex and antibody
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Multimeric state: hetero pentamer
Accessible surface area: 161380.86 Å2
Buried surface area: 35547.2 Å2
Dissociation area: 1,299.57 Å2
Dissociation energy (ΔGdiss): -11.67 kcal/mol
Dissociation entropy (TΔSdiss): 24.69 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-210402

Macromolecules

Spike glycoprotein
Chains: A, B, C
Length: 1288 amino acids
Theoretical weight: 142.32 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1208; Coverage: 95%)
Gene names: 2, S
Pfam:
InterPro:
Spike glycoprotein in PDB entry 7y7j, assembly 1, front view.
Spike glycoprotein in PDB entry 7y7j, assembly 1, side view.
Spike glycoprotein in PDB entry 7y7j, assembly 1, top view.
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1F VH
Chain: E
Length: 132 amino acids
Theoretical weight: 14.52 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
1F VH in PDB entry 7y7j, assembly 1, front view.
1F VH in PDB entry 7y7j, assembly 1, side view.
1F VH in PDB entry 7y7j, assembly 1, top view.
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1F VL
Chain: D
Length: 111 amino acids
Theoretical weight: 11.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
1F VL in PDB entry 7y7j, assembly 1, front view.
1F VL in PDB entry 7y7j, assembly 1, side view.
1F VL in PDB entry 7y7j, assembly 1, top view.
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