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CryoEM structure of SPCA1a in E1-Ca-AMPPCP state subclass 3

Source organisms:
Biochemical function: P-type manganese transporter activity
Biological process: trans-Golgi network membrane organization
Cellular component: cis-Golgi network membrane

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EC 7.2.2.10: P-type Ca(2+) transporter

Reaction catalysed:
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Systematic name:
ATP phosphohydrolase (P-type, Ca(2+)-transporting)
Alternative Name(s):
  • Ca(2+)-pumping ATPase
  • Ca(2+)-transporting ATPase
  • Calcium pump
  • Calcium-translocating P-type ATPase
  • Plasma membrane Ca-ATPase
  • Sarco(endo)plasmic reticulum Ca(2+)-ATPase
  • Sarcoplasmic reticulum ATPase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00689
Domain description: Cation transporting ATPase, C-terminus
Occurring in:
  1. Calcium-transporting ATPase type 2C member 1
The deposited structure of PDB entry 7yai contains 1 copy of Pfam domain PF00689 (Cation transporting ATPase, C-terminus) in Calcium-transporting ATPase type 2C member 1. Showing 1 copy in chain A.

PF13246
Domain description: Cation transport ATPase (P-type)
Occurring in:
  1. Calcium-transporting ATPase type 2C member 1

PF00122
Domain description: E1-E2 ATPase
Occurring in:
  1. Calcium-transporting ATPase type 2C member 1
The deposited structure of PDB entry 7yai contains 1 copy of Pfam domain PF00122 (E1-E2 ATPase) in Calcium-transporting ATPase type 2C member 1. Showing 1 copy in chain A.

PF00690
Domain description: Cation transporter/ATPase, N-terminus
Occurring in:
  1. Calcium-transporting ATPase type 2C member 1
The deposited structure of PDB entry 7yai contains 1 copy of Pfam domain PF00690 (Cation transporter/ATPase, N-terminus) in Calcium-transporting ATPase type 2C member 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001757
Domain description: P-type ATPase
Occurring in:
  1. Calcium-transporting ATPase type 2C member 1
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Nanobody head piece of megabody
IPR004014
Domain description: Cation-transporting P-type ATPase, N-terminal
Occurring in:
  1. Calcium-transporting ATPase type 2C member 1
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. Nanobody head piece of megabody
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Nanobody head piece of megabody
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Nanobody head piece of megabody
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Nanobody head piece of megabody
IPR006068
Domain description: Cation-transporting P-type ATPase, C-terminal
Occurring in:
  1. Calcium-transporting ATPase type 2C member 1
IPR023299
Domain description: P-type ATPase, cytoplasmic domain N
Occurring in:
  1. Calcium-transporting ATPase type 2C member 1
IPR018303
Domain description: P-type ATPase, phosphorylation site
Occurring in:
  1. Calcium-transporting ATPase type 2C member 1
IPR036412
Domain description: HAD-like superfamily
Occurring in:
  1. Calcium-transporting ATPase type 2C member 1
IPR023214
Domain description: HAD superfamily
Occurring in:
  1. Calcium-transporting ATPase type 2C member 1
IPR044492
Domain description: P-type ATPase, haloacid dehalogenase domain
Occurring in:
  1. Calcium-transporting ATPase type 2C member 1
IPR008250
Domain description: P-type ATPase, A domain superfamily
Occurring in:
  1. Calcium-transporting ATPase type 2C member 1
IPR023298
Domain description: P-type ATPase, transmembrane domain superfamily
Occurring in:
  1. Calcium-transporting ATPase type 2C member 1
IPR006413
Domain description: P-type ATPase, subfamily IIA, PMR1-type
Occurring in:
  1. Calcium-transporting ATPase type 2C member 1

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