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Cryo-EM structure of the C-terminal domain of the human sodium-chloride cotransporter

Electron Microscopy
3.77Å resolution
PDB entry 7yg1 coloured by chain, front view.
PDB entry 7yg1 coloured by chain, side view.
PDB entry 7yg1 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Solute carrier family 12 member 3
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Multimeric state: homo dimer
Accessible surface area: 36074.03 Å2
Buried surface area: 4481.99 Å2
Dissociation area: 2,240.99 Å2
Dissociation energy (ΔGdiss): 19.63 kcal/mol
Dissociation entropy (TΔSdiss): 14.06 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-157149

Macromolecules

Solute carrier family 12 member 3
Chains: A, B
Length: 1053 amino acids
Theoretical weight: 116.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P55017 (Residues: 1-1021; Coverage: 100%)
Gene names: NCC, SLC12A3, TSC
Pfam:
InterPro:
Solute carrier family 12 member 3 in PDB entry 7yg1, assembly 1, front view.
Solute carrier family 12 member 3 in PDB entry 7yg1, assembly 1, side view.
Solute carrier family 12 member 3 in PDB entry 7yg1, assembly 1, top view.
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