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CCA-bound alpha-synuclein fibrils

Electron Microscopy
2.5Å resolution
PDB entry 7ynf coloured by chain, front view.
PDB entry 7ynf coloured by chain, side view.
PDB entry 7ynf coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo hexamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Alpha-synuclein
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Multimeric state: homo hexamer
Accessible surface area: 21100.57 Å2
Buried surface area: 22253.5 Å2
Dissociation area: 1,224.91 Å2
Dissociation energy (ΔGdiss): 4.22 kcal/mol
Dissociation entropy (TΔSdiss): 12.53 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153511

Macromolecules

Alpha-synuclein
Chains: A, B, C, D, E, F
Length: 140 amino acids
Theoretical weight: 14.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37840 (Residues: 1-140; Coverage: 100%)
Gene names: NACP, PARK1, SNCA
Pfam: Synuclein
Alpha-synuclein in PDB entry 7ynf, assembly 1, front view.
Alpha-synuclein in PDB entry 7ynf, assembly 1, side view.
Alpha-synuclein in PDB entry 7ynf, assembly 1, top view.
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