› 7yoy

Electron Microscopy
3.64Å resolution

Cryo-EM structure of EBV gHgL-gp42 in complex with mAbs 3E8 and 5E3 (localized refinement)

Released:
DOI: 10.2210/pdb7yoy/pdb
PDB entry 7yoy coloured by chain, front view.
PDB entry 7yoy coloured by chain, side view.
PDB entry 7yoy coloured by chain, top view.
Source organisms:
Primary publication:
Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection.
Hong J, Zhong L, Liu L, Wu Q, Zhang W, Chen K, Wei D, Sun H, Zhou X, Zhang X, Kang YF, Huang Y, Chen J, Wang G, Zhou Y, Chen Y, Feng QS, Yu H, Li S, Zeng MS, Zeng YX, Xu M, Zheng Q, Chen Y, Zhang X, Xia N
Cell Rep Med 4 101296 (2023)
PMID: 37992686
Related structures: EMD-33990

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-243716 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Soluble gp42 Chain: C
Molecule details ›
Chain: C
Length: 136 amino acids
Theoretical weight: 15.59 KDa
Source organism: human gammaherpesvirus 4
Expression system: Homo sapiens
UniProt:
  • Canonical: P03205 (Residues: 88-223; Coverage: 61%)
Gene name: BZLF2
5E3 heavy chain Chain: E
Molecule details ›
Chain: E
Length: 121 amino acids
Theoretical weight: 13.15 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens
3E8 heavy chain Chain: F
Molecule details ›
Chain: F
Length: 113 amino acids
Theoretical weight: 12.12 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens
5E3 light chain Chain: I
Molecule details ›
Chain: I
Length: 111 amino acids
Theoretical weight: 11.54 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens
3E8 light chain Chain: J
Molecule details ›
Chain: J
Length: 112 amino acids
Theoretical weight: 11.83 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.64Å
Relevant EMDB volumes: EMD-33990
Expression system: Homo sapiens

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