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Cryo-EM structure of EBV gHgL-gp42 in complex with mAbs 3E8 and 5E3 (localized refinement)

Electron Microscopy
3.64Å resolution
PDB entry 7yoy coloured by chain, front view.
PDB entry 7yoy coloured by chain, side view.
PDB entry 7yoy coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Soluble gp42 and IG-heavy chain and IG-heavy chain and IG-light kappa chain and IG-light kappa chain
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Multimeric state: hetero pentamer
Accessible surface area: 27097.68 Å2
Buried surface area: 6891.26 Å2
Dissociation area: 1,716.18 Å2
Dissociation energy (ΔGdiss): -7.6 kcal/mol
Dissociation entropy (TΔSdiss): 24.75 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-243716

Macromolecules

Soluble gp42
Chain: C
Length: 136 amino acids
Theoretical weight: 15.59 KDa
Source organism: human gammaherpesvirus 4
Expression system: Homo sapiens
UniProt:
  • Canonical: P03205 (Residues: 88-223; Coverage: 61%)
Gene name: BZLF2
Soluble gp42 in PDB entry 7yoy, assembly 1, front view.
Soluble gp42 in PDB entry 7yoy, assembly 1, side view.
Soluble gp42 in PDB entry 7yoy, assembly 1, top view.
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5E3 heavy chain
Chain: E
Length: 121 amino acids
Theoretical weight: 13.15 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens
5E3 heavy chain in PDB entry 7yoy, assembly 1, front view.
5E3 heavy chain in PDB entry 7yoy, assembly 1, side view.
5E3 heavy chain in PDB entry 7yoy, assembly 1, top view.
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3E8 heavy chain
Chain: F
Length: 113 amino acids
Theoretical weight: 12.12 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens
3E8 heavy chain in PDB entry 7yoy, assembly 1, front view.
3E8 heavy chain in PDB entry 7yoy, assembly 1, side view.
3E8 heavy chain in PDB entry 7yoy, assembly 1, top view.
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5E3 light chain
Chain: I
Length: 111 amino acids
Theoretical weight: 11.54 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens
5E3 light chain in PDB entry 7yoy, assembly 1, front view.
5E3 light chain in PDB entry 7yoy, assembly 1, side view.
5E3 light chain in PDB entry 7yoy, assembly 1, top view.
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3E8 light chain
Chain: J
Length: 112 amino acids
Theoretical weight: 11.83 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens
3E8 light chain in PDB entry 7yoy, assembly 1, front view.
3E8 light chain in PDB entry 7yoy, assembly 1, side view.
3E8 light chain in PDB entry 7yoy, assembly 1, top view.
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