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Omicron BA.4/5 SARS-CoV-2 S in complex with TH132 Fab

Electron Microscopy
3.4Å resolution
PDB entry 7yvg coloured by chain, front view.
PDB entry 7yvg coloured by chain, side view.
PDB entry 7yvg coloured by chain, top view.
Source organisms:
Assembly composition:
hetero nonamer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: SARS-CoV-2 post-fusion S2 Spike complex and antibody
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Multimeric state: hetero nonamer
Accessible surface area: 171199.65 Å2
Buried surface area: 37460.35 Å2
Dissociation area: 2,262.5 Å2
Dissociation energy (ΔGdiss): -8.23 kcal/mol
Dissociation entropy (TΔSdiss): 40.85 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-225418

Macromolecules

Spike glycoprotein
Chains: A, B, C
Length: 1288 amino acids
Theoretical weight: 142.59 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1208; Coverage: 95%)
Gene names: 2, S
Pfam:
Spike glycoprotein in PDB entry 7yvg, assembly 1, front view.
Spike glycoprotein in PDB entry 7yvg, assembly 1, side view.
Spike glycoprotein in PDB entry 7yvg, assembly 1, top view.
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TH132 Fab light chain
Chains: H, J, L
Length: 109 amino acids
Theoretical weight: 11.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
TH132 Fab light chain in PDB entry 7yvg, assembly 1, front view.
TH132 Fab light chain in PDB entry 7yvg, assembly 1, side view.
TH132 Fab light chain in PDB entry 7yvg, assembly 1, top view.
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TH132 Fab heavy chain
Chains: I, K, M
Length: 118 amino acids
Theoretical weight: 12.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
TH132 Fab heavy chain in PDB entry 7yvg, assembly 1, front view.
TH132 Fab heavy chain in PDB entry 7yvg, assembly 1, side view.
TH132 Fab heavy chain in PDB entry 7yvg, assembly 1, top view.
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