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Tetragonal crystal structure of YTHDF1 YTH domain (544AVV546 mutant)

X-ray diffraction
2.1Å resolution
PDB entry 7yyj coloured by chain, front view.
PDB entry 7yyj coloured by chain, side view.
PDB entry 7yyj coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: YTH domain-containing family protein 1
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Multimeric state: monomeric
Accessible surface area: 10761.24 Å2
Buried surface area: 778.56 Å2
Dissociation area: 106.64 Å2
Dissociation energy (ΔGdiss): -2.69 kcal/mol
Dissociation entropy (TΔSdiss): -0.25 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-189836
Assembly 2 (preferred)
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Assembly Name: YTH domain-containing family protein 1
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Multimeric state: monomeric
Accessible surface area: 10614.35 Å2
Buried surface area: 451.7 Å2
Dissociation area: 105.9 Å2
Dissociation energy (ΔGdiss): -2.73 kcal/mol
Dissociation entropy (TΔSdiss): -0.28 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-189836

Macromolecules

YTH domain-containing family protein 1
Chains: A, B
Length: 200 amino acids
Theoretical weight: 23.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9BYJ9 (Residues: 361-559; Coverage: 36%)
  • Best match: Q9BYJ9-2 (Residues: 176-197)
Gene names: C20orf21, YTHDF1
Pfam: YT521-B-like domain
InterPro:
YTH domain-containing family protein 1 in PDB entry 7yyj, assembly 2, front view.
YTH domain-containing family protein 1 in PDB entry 7yyj, assembly 2, side view.
YTH domain-containing family protein 1 in PDB entry 7yyj, assembly 2, top view.
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