Structure analysis

Cryo-EM structure of NNRTI resistant M184I/E138K mutant HIV-1 reverse transcriptase with a DNA aptamer in complex with nevirapine

Electron Microscopy
3.38Å resolution
Assembly composition:
hetero trimer (preferred)
Entry contents: 2 distinct polypeptide molecules
1 distinct DNA molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 48777.55 Å2
Buried surface area: 10678.2 Å2
Dissociation area: 1,907.03 Å2
Dissociation energy (ΔGdiss): 17.32 kcal/mol
Dissociation entropy (TΔSdiss): 12.72 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-122367

Macromolecules

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Name: DNA (38-MER)
Representative chains: E
Length: 38 nucleotides
Theoretical weight: 11.75 KDa

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