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Cryo-EM structure of NNRTI resistant M184I/E138K mutant HIV-1 reverse transcriptase with a DNA aptamer in complex with rilpivirine

Electron Microscopy
3.45Å resolution
PDB entry 7z2e coloured by chain, front view.
PDB entry 7z2e coloured by chain, side view.
PDB entry 7z2e coloured by chain, top view.
Source organism: Human immunodeficiency virus type 1 BH10
Assembly composition:
hetero trimer (preferred)
Entry contents: 2 distinct polypeptide molecules
1 distinct DNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protease and DNA
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Multimeric state: hetero trimer
Accessible surface area: 51519.44 Å2
Buried surface area: 9330.55 Å2
Dissociation area: 2,762.86 Å2
Dissociation energy (ΔGdiss): 16.81 kcal/mol
Dissociation entropy (TΔSdiss): 15.14 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-270266

Macromolecules

Reverse transcriptase/ribonuclease H
Chain: A
Length: 556 amino acids
Theoretical weight: 64.02 KDa
Source organism: Human immunodeficiency virus type 1 BH10
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03366 (Residues: 600-1153; Coverage: 38%)
Gene name: gag-pol
Pfam:
InterPro:
Reverse transcriptase/ribonuclease H in PDB entry 7z2e, assembly 1, front view.
Reverse transcriptase/ribonuclease H in PDB entry 7z2e, assembly 1, side view.
Reverse transcriptase/ribonuclease H in PDB entry 7z2e, assembly 1, top view.
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p51 RT
Chain: B
Length: 428 amino acids
Theoretical weight: 50.04 KDa
Source organism: Human immunodeficiency virus type 1 BH10
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03366 (Residues: 600-1027; Coverage: 30%)
Gene name: gag-pol
Pfam:
InterPro:
p51 RT in PDB entry 7z2e, assembly 1, front view.
p51 RT in PDB entry 7z2e, assembly 1, side view.
p51 RT in PDB entry 7z2e, assembly 1, top view.
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DNA chain E
Name: DNA (38-MER)
Representative chains: E
Length: 38 nucleotides
Theoretical weight: 11.75 KDa
DNA (38-MER) in PDB entry 7z2e, assembly 1, front view.
DNA (38-MER) in PDB entry 7z2e, assembly 1, side view.
DNA (38-MER) in PDB entry 7z2e, assembly 1, top view.
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