Function and Biology Details
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Heat shock protein Hsp90, N-terminal
- Heat shock protein Hsp90 family
- Diacylglycerol/phorbol-ester binding
- HSP90, C-terminal domain
- Histidine kinase/HSP90-like ATPase
- Histidine kinase/HSP90-like ATPase superfamily
- Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
- Cdc37, C-terminal
14 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-137336 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Heat shock protein HSP 90-beta
Molecule details ›
RAF proto-oncogene serine/threonine-protein kinase
Molecule details ›
Chain: C
Length: 659 amino acids
Theoretical weight: 74.41 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 659 amino acids
Theoretical weight: 74.41 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
P04049 (Residues: 1-648; Coverage: 100%)
Sequence domains:
Hsp90 co-chaperone Cdc37
Molecule details ›
Chain: D
Length: 394 amino acids
Theoretical weight: 46.54 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 394 amino acids
Theoretical weight: 46.54 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q16543 (Residues: 1-378; Coverage: 100%)
Sequence domains:
