› › Structure analysis

Structure of the RAF1-HSP90-CDC37 complex (RHC-I)

Electron Microscopy
3.16Å resolution
PDB entry 7z38 coloured by chain, front view.
PDB entry 7z38 coloured by chain, side view.
PDB entry 7z38 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 3 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero tetramer
Accessible surface area: 78114.18 Å2
Buried surface area: 22187.96 Å2
Dissociation area: 2,692.08 Å2
Dissociation energy (ΔGdiss): 22.09 kcal/mol
Dissociation entropy (TΔSdiss): 14.42 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137336

Macromolecules

Heat shock protein HSP 90-beta
Chains: A, B
Length: 732 amino acids
Theoretical weight: 84.37 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08238 (Residues: 3-724; Coverage: 100%)
Gene names: HSP90AB1, HSP90B, HSPC2, HSPC3, HSPCB
Pfam:
InterPro:
Heat shock protein HSP 90-beta in PDB entry 7z38, assembly 1, front view.
Heat shock protein HSP 90-beta in PDB entry 7z38, assembly 1, side view.
Heat shock protein HSP 90-beta in PDB entry 7z38, assembly 1, top view.
Molecule details ›

Search similar proteins

RAF proto-oncogene serine/threonine-protein kinase
Chain: C
Length: 659 amino acids
Theoretical weight: 74.41 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P04049 (Residues: 1-648; Coverage: 100%)
Gene names: RAF, RAF1
Pfam:
InterPro:
RAF proto-oncogene serine/threonine-protein kinase in PDB entry 7z38, assembly 1, front view.
RAF proto-oncogene serine/threonine-protein kinase in PDB entry 7z38, assembly 1, side view.
RAF proto-oncogene serine/threonine-protein kinase in PDB entry 7z38, assembly 1, top view.
Molecule details ›

Search similar proteins

Hsp90 co-chaperone Cdc37
Chain: D
Length: 394 amino acids
Theoretical weight: 46.54 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q16543 (Residues: 1-378; Coverage: 100%)
Gene names: CDC37, CDC37A
Pfam:
InterPro:
Hsp90 co-chaperone Cdc37 in PDB entry 7z38, assembly 1, front view.
Hsp90 co-chaperone Cdc37 in PDB entry 7z38, assembly 1, side view.
Hsp90 co-chaperone Cdc37 in PDB entry 7z38, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links