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Human cytosolic 5' nucleotidase IIIB in complex with 3,4-diF-Bn7Guanine

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: nucleotide metabolic process
Cellular component: cytosol

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EC 3.1.3.91: 7-methylguanosine nucleotidase

Reaction catalysed:
CMP + H(2)O = cytidine + phosphate
Systematic name:
N(7)-methyl-GMP phosphohydrolase
Alternative Name(s):
  • CNIII-like
  • Cytosolic nucleotidase III-like
  • N(7)-methylguanylate 5'-phosphatase

EC 3.1.3.5: 5'-nucleotidase

Reaction catalysed:
A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate
Systematic name:
5'-ribonucleotide phosphohydrolase
Alternative Name(s):
  • 5'-AMP nucleotidase
  • 5'-AMPase
  • 5'-adenylic phosphatase
  • 5'-mononucleotidase
  • AMP phosphatase
  • AMP phosphohydrolase
  • AMPase
  • Adenosine 5'-phosphatase
  • Adenosine monophosphatase
  • IMP 5'-nucleotidase
  • Snake venom 5'-nucleotidase
  • Thimidine monophosphate nucleotidase
  • UMPase
  • Uridine 5'-nucleotidase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF05822
Domain description: Pyrimidine 5'-nucleotidase (UMPH-1)
Occurring in:
  1. 7-methylguanosine phosphate-specific 5'-nucleotidase
The deposited structure of PDB entry 7zeh contains 4 copies of Pfam domain PF05822 (Pyrimidine 5'-nucleotidase (UMPH-1)) in 7-methylguanosine phosphate-specific 5'-nucleotidase. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR006434
Domain description: Pyrimidine 5'-nucleotidase, eukaryotic
Occurring in:
  1. 7-methylguanosine phosphate-specific 5'-nucleotidase
IPR023214
Domain description: HAD superfamily
Occurring in:
  1. 7-methylguanosine phosphate-specific 5'-nucleotidase
IPR036412
Domain description: HAD-like superfamily
Occurring in:
  1. 7-methylguanosine phosphate-specific 5'-nucleotidase

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