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Human cytosolic 5' nucleotidase IIIB in complex with 3,4-diF-Bn7Guanine

X-ray diffraction
1.5Å resolution
PDB entry 7zeh coloured by chain, front view.
PDB entry 7zeh coloured by chain, side view.
PDB entry 7zeh coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: 7-methylguanosine phosphate-specific 5'-nucleotidase
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Multimeric state: monomeric
Accessible surface area: 12974.12 Å2
Buried surface area: 1578.47 Å2
Dissociation area: 104.92 Å2
Dissociation energy (ΔGdiss): -2.97 kcal/mol
Dissociation entropy (TΔSdiss): -0.28 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-188343
Assembly 2 (preferred)
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Assembly Name: 7-methylguanosine phosphate-specific 5'-nucleotidase
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Multimeric state: monomeric
Accessible surface area: 12645.34 Å2
Buried surface area: 1536.19 Å2
Dissociation area: 84.38 Å2
Dissociation energy (ΔGdiss): -2.63 kcal/mol
Dissociation entropy (TΔSdiss): -0.39 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-188343
Assembly 3
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Assembly Name: 7-methylguanosine phosphate-specific 5'-nucleotidase
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Multimeric state: monomeric
Accessible surface area: 13129.67 Å2
Buried surface area: 2439.72 Å2
Dissociation area: 211.63 Å2
Dissociation energy (ΔGdiss): -7.69 kcal/mol
Dissociation entropy (TΔSdiss): 2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-188343
Assembly 4
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Assembly Name: 7-methylguanosine phosphate-specific 5'-nucleotidase
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Multimeric state: monomeric
Accessible surface area: 13183.65 Å2
Buried surface area: 1910.69 Å2
Dissociation area: 94.26 Å2
Dissociation energy (ΔGdiss): -3.21 kcal/mol
Dissociation entropy (TΔSdiss): -0.26 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-188343

Macromolecules

7-methylguanosine phosphate-specific 5'-nucleotidase
Chains: A, B, C, D
Length: 302 amino acids
Theoretical weight: 34.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q969T7 (Residues: 1-300; Coverage: 100%)
Gene names: NT5C3B, NT5C3L
Pfam: Pyrimidine 5'-nucleotidase (UMPH-1)
InterPro:
7-methylguanosine phosphate-specific 5'-nucleotidase in PDB entry 7zeh, assembly 2, front view.
7-methylguanosine phosphate-specific 5'-nucleotidase in PDB entry 7zeh, assembly 2, side view.
7-methylguanosine phosphate-specific 5'-nucleotidase in PDB entry 7zeh, assembly 2, top view.
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