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ABCB1 L335C mutant (mABCB1) in the outward facing state bound to AAC

Electron Microscopy
2.6Å resolution
PDB entry 7zk5 coloured by chain, front view.
PDB entry 7zk5 coloured by chain, side view.
PDB entry 7zk5 coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: ATP-dependent translocase ABCB1
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Multimeric state: monomeric
Accessible surface area: 45905.45 Å2
Buried surface area: 2092.44 Å2
Dissociation area: 152.36 Å2
Dissociation energy (ΔGdiss): 23.7 kcal/mol
Dissociation entropy (TΔSdiss): -2.91 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149243

Macromolecules

ATP-dependent translocase ABCB1
Chain: A
Length: 1328 amino acids
Theoretical weight: 146.06 KDa
Source organism: Mus musculus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P21447 (Residues: 1-1276; Coverage: 100%)
Gene names: Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3
Pfam:
InterPro:
ATP-dependent translocase ABCB1 in PDB entry 7zk5, assembly 1, front view.
ATP-dependent translocase ABCB1 in PDB entry 7zk5, assembly 1, side view.
ATP-dependent translocase ABCB1 in PDB entry 7zk5, assembly 1, top view.
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