› 7zku

X-ray diffraction
1.7Å resolution

Crystal structure of human STING in complex with 3',3'-c-(2'F,2'dAMP-2'dGMP)

Released:
DOI: 10.2210/pdb7zku/pdb
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PDB entry 7zku coloured by chain, front view.
PDB entry 7zku coloured by chain, side view.
PDB entry 7zku coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Klima M, Smola M, Boura E

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 204 amino acids
Theoretical weight: 23.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q86WV6 (Residues: 140-343; Coverage: 54%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Sequence domains: Transmembrane protein 173

Ligands and Environments

1 bound ligand:
Ligand JLU 1 x JLU
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P6522
Unit cell:
a: 93.158Å b: 93.158Å c: 204.062Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.223 0.222 0.244
Expression system: Escherichia coli BL21(DE3)

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