Structure analysis

Crystal structure of human STING in complex with 3',3'-c-(2'F,2'dAMP-2'dGMP)

X-ray diffraction
1.7Å resolution
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 16903.18 Å2
Buried surface area: 4078.2 Å2
Dissociation area: 2,039.1 Å2
Dissociation energy (ΔGdiss): 14.81 kcal/mol
Dissociation entropy (TΔSdiss): 12.9 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-183240
Complex Portal ID: CPX-2127

Macromolecules

Chains: A, B
Length: 204 amino acids
Theoretical weight: 23.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q86WV6 (Residues: 140-343; Coverage: 54%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Pfam: Transmembrane protein 173

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