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HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound

X-ray diffraction
2.48Å resolution
PDB entry 7zuq coloured by chain, front view.
PDB entry 7zuq coloured by chain, side view.
PDB entry 7zuq coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Methylosome protein WDR77 and Protein arginine N-methyltransferase 5
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Multimeric state: hetero dimer
Accessible surface area: 36399.22 Å2
Buried surface area: 5965.38 Å2
Dissociation area: 2,036.23 Å2
Dissociation energy (ΔGdiss): 16.28 kcal/mol
Dissociation entropy (TΔSdiss): 14.04 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127075

Macromolecules

Protein arginine N-methyltransferase 5
Chain: A
Length: 645 amino acids
Theoretical weight: 73.76 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O14744 (Residues: 2-637; Coverage: 100%)
Gene names: HRMT1L5, IBP72, JBP1, PRMT5, SKB1
Pfam:
InterPro:
Protein arginine N-methyltransferase 5 in PDB entry 7zuq, assembly 1, front view.
Protein arginine N-methyltransferase 5 in PDB entry 7zuq, assembly 1, side view.
Protein arginine N-methyltransferase 5 in PDB entry 7zuq, assembly 1, top view.
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Methylosome protein WDR77
Chain: B
Length: 350 amino acids
Theoretical weight: 37.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9BQA1 (Residues: 2-342; Coverage: 100%)
Gene names: HKMT1069, MEP50, Nbla10071, WD45, WDR77
Pfam: WD domain, G-beta repeat
InterPro:
Methylosome protein WDR77 in PDB entry 7zuq, assembly 1, front view.
Methylosome protein WDR77 in PDB entry 7zuq, assembly 1, side view.
Methylosome protein WDR77 in PDB entry 7zuq, assembly 1, top view.
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