› 8blb

Electron Microscopy
3.3Å resolution

Human serotonin 5-HT3A receptor in complex with vortioxetine (nanodiscs, ECD, active/distorted conformation)

Released:
DOI: 10.2210/pdb8blb/pdb
PDB entry 8blb coloured by chain, front view.
PDB entry 8blb coloured by chain, side view.
PDB entry 8blb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT3 receptors.
López-Sánchez U, Munro LJ, Ladefoged LK, Pedersen AJ, Brun CC, Lyngby SM, Baud D, Juillan-Binard C, Pedersen MG, Lummis SCR, Bang-Andersen B, Schiøtt B, Chipot C, Schoehn G, Neyton J, Dehez F, Nury H, Kristensen AS
Nat Struct Mol Biol (2024)
PMID: 38698207
Related structures: EMD-16105

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-240854 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
5-hydroxytryptamine receptor 3A Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 450 amino acids
Theoretical weight: 52.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P46098 (Residues: 29-478; Coverage: 99%)
Gene names: 5HT3R, HTR3, HTR3A
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand NAG 5 x NAG
Ligand VTX 5 x VTX
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-16105
Expression system: Homo sapiens

Quick links