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Human serotonin 5-HT3A receptor in complex with vortioxetine (nanodiscs, ECD, active/distorted conformation)

Electron Microscopy
3.3Å resolution
PDB entry 8blb coloured by chain, front view.
PDB entry 8blb coloured by chain, side view.
PDB entry 8blb coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo pentamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 5-hydroxytryptamine-3A receptor complex
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Multimeric state: homo pentamer
Accessible surface area: 45904.02 Å2
Buried surface area: 22716.88 Å2
Dissociation area: 8,115.06 Å2
Dissociation energy (ΔGdiss): 68.63 kcal/mol
Dissociation entropy (TΔSdiss): 55.9 kcal/mol
Symmetry number: 5
PDBe Complex ID: PDB-CPX-240854
Complex Portal ID: CPX-2175

Macromolecules

5-hydroxytryptamine receptor 3A
Chains: A, B, C, D, E
Length: 450 amino acids
Theoretical weight: 52.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P46098 (Residues: 29-478; Coverage: 99%)
Gene names: 5HT3R, HTR3, HTR3A
Pfam:
5-hydroxytryptamine receptor 3A in PDB entry 8blb, assembly 1, front view.
5-hydroxytryptamine receptor 3A in PDB entry 8blb, assembly 1, side view.
5-hydroxytryptamine receptor 3A in PDB entry 8blb, assembly 1, top view.
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