PDB 8szh structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Biochemical function:

G protein-coupled receptor activity

Biological process:

G protein-coupled receptor signaling pathway

Cellular component:

membrane

Structure analysis Details

Assembly composition:

hetero pentamer (preferred)

PDBe Complex ID:

PDB-CPX-530884 (preferred)

Entry contents:

4 distinct polypeptide molecules

Macromolecules (5 distinct):

Extracellular calcium-sensing receptor Chains: A, B

Molecule details ›

Chains: A, B
Length: 886 amino acids
Theoretical weight: 99.93 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:

Canonical: P41180 (Residues: 19-894; Coverage: 83%)

Gene names: CASR, GPRC2A, PCAR1
Sequence domains:

Guanine nucleotide-binding protein G(i) subunit alpha-3 Chain: C

Molecule details ›

Chain: C
Length: 354 amino acids
Theoretical weight: 40.59 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:

Canonical: P08754 (Residues: 1-354; Coverage: 100%)

Gene name: GNAI3
Sequence domains: G-protein alpha subunit

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: D

Molecule details ›

Chain: D
Length: 343 amino acids
Theoretical weight: 37.57 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:

Canonical: P62873 (Residues: 2-340; Coverage: 100%)

Gene name: GNB1
Sequence domains: WD domain, G-beta repeat

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: E

Molecule details ›

Chain: E
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt: