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Cryo-EM structure of cinacalcet-bound human calcium-sensing receptor CaSR-Gi complex in lipid nanodiscs

Electron Microscopy
3.1Å resolution
PDB entry 8szh coloured by chain, front view.
PDB entry 8szh coloured by chain, side view.
PDB entry 8szh coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero pentamer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 103509.36 Å2
Buried surface area: 24988.11 Å2
Dissociation area: 1,142.92 Å2
Dissociation energy (ΔGdiss): 1.13 kcal/mol
Dissociation entropy (TΔSdiss): 14.79 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-239654

Macromolecules

Extracellular calcium-sensing receptor
Chains: A, B
Length: 886 amino acids
Theoretical weight: 99.93 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P41180 (Residues: 19-894; Coverage: 83%)
Gene names: CASR, GPRC2A, PCAR1
Pfam:
Extracellular calcium-sensing receptor in PDB entry 8szh, assembly 1, front view.
Extracellular calcium-sensing receptor in PDB entry 8szh, assembly 1, side view.
Extracellular calcium-sensing receptor in PDB entry 8szh, assembly 1, top view.
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Guanine nucleotide-binding protein G(i) subunit alpha-3
Chain: C
Length: 354 amino acids
Theoretical weight: 40.59 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P08754 (Residues: 1-354; Coverage: 100%)
Gene name: GNAI3
Pfam: G-protein alpha subunit
Guanine nucleotide-binding protein G(i) subunit alpha-3 in PDB entry 8szh, assembly 1, front view.
Guanine nucleotide-binding protein G(i) subunit alpha-3 in PDB entry 8szh, assembly 1, side view.
Guanine nucleotide-binding protein G(i) subunit alpha-3 in PDB entry 8szh, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Chain: D
Length: 343 amino acids
Theoretical weight: 37.57 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62873 (Residues: 2-340; Coverage: 100%)
Gene name: GNB1
Pfam: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8szh, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8szh, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 in PDB entry 8szh, assembly 1, top view.
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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Chain: E
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P59768 (Residues: 1-71; Coverage: 100%)
Gene name: GNG2
Pfam: GGL domain
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8szh, assembly 1, front view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8szh, assembly 1, side view.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 in PDB entry 8szh, assembly 1, top view.
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