› 8yqq

Electron Microscopy
3.95Å resolution

Structure of HKU1B RBD with TMPRSS2

Released:
DOI: 10.2210/pdb8yqq/pdb
PDB entry 8yqq coloured by chain, front view.
PDB entry 8yqq coloured by chain, side view.
PDB entry 8yqq coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for the interaction between human coronavirus HKU1 spike receptor binding domain and its receptor TMPRSS2.
Gao X, Zhu K, Wang L, Shang K, Hua L, Qin B, Zhu H, Ding W, Cui S
Cell Discov 10 84 (2024)
PMID: 39112468
Related structures: EMD-39502

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-271597 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Spike protein S1 Chain: A
Molecule details ›
Chain: A
Length: 285 amino acids
Theoretical weight: 31.7 KDa
Source organism: Candidatus Accumulibacter adiacens
Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: Q0ZME7 (Residues: 323-607; Coverage: 21%)
Gene names: 3, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding
Transmembrane protease serine 2 non-catalytic chain Chain: B
Molecule details ›
Chain: B
Length: 384 amino acids
Theoretical weight: 42.38 KDa
Source organism: Homo sapiens
Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: O15393 (Residues: 109-492; Coverage: 78%)
Gene names: PRSS10, TMPRSS2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 6 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.95Å
Relevant EMDB volumes: EMD-39502
Expression system: Baculovirus expression vector pFastBac1-HM

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