Structure analysis

Structure of HKU1B RBD with TMPRSS2

Electron Microscopy
3.95Å resolution
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 30784.57 Å2
Buried surface area: 2512.05 Å2
Dissociation area: 737.99 Å2
Dissociation energy (ΔGdiss): -4.08 kcal/mol
Dissociation entropy (TΔSdiss): 13.18 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-271597

Macromolecules

Chain: A
Length: 285 amino acids
Theoretical weight: 31.7 KDa
Source organism: Candidatus Accumulibacter adiacens
Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: Q0ZME7 (Residues: 323-607; Coverage: 21%)
Gene names: 3, S
Pfam: Betacoronavirus spike glycoprotein S1, receptor binding

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Chain: B
Length: 384 amino acids
Theoretical weight: 42.38 KDa
Source organism: Homo sapiens
Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: O15393 (Residues: 109-492; Coverage: 78%)
Gene names: PRSS10, TMPRSS2
Pfam:

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