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Crystal structure of human Cathepsin L with covalently bound Calpain inhibitor III

X-ray diffraction
1.8Å resolution
PDB entry 8a4x coloured by chain, front view.
PDB entry 8a4x coloured by chain, side view.
PDB entry 8a4x coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Procathepsin L
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Multimeric state: monomeric
Accessible surface area: 10026.1 Å2
Buried surface area: 817.05 Å2
Dissociation area: 178.3 Å2
Dissociation energy (ΔGdiss): -7.35 kcal/mol
Dissociation entropy (TΔSdiss): 3.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139718
Assembly 2
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Assembly Name: Procathepsin L
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Multimeric state: monomeric
Accessible surface area: 9533.38 Å2
Buried surface area: 930.18 Å2
Dissociation area: 137.93 Å2
Dissociation energy (ΔGdiss): -5.48 kcal/mol
Dissociation entropy (TΔSdiss): 1.56 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139718
Assembly 3
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Assembly Name: Procathepsin L
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Multimeric state: monomeric
Accessible surface area: 9336.33 Å2
Buried surface area: 1043.82 Å2
Dissociation area: 141.71 Å2
Dissociation energy (ΔGdiss): -5.28 kcal/mol
Dissociation entropy (TΔSdiss): 1.61 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139718
Assembly 4
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Assembly Name: Procathepsin L
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Multimeric state: monomeric
Accessible surface area: 9756.46 Å2
Buried surface area: 574.15 Å2
Dissociation area: 287.08 Å2
Dissociation energy (ΔGdiss): -5.74 kcal/mol
Dissociation entropy (TΔSdiss): 4.23 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139718

Macromolecules

Cathepsin L
Chains: A, B, C, D
Length: 220 amino acids
Theoretical weight: 24.16 KDa
Source organism: Homo sapiens
Expression system: Komagataella phaffii GS115
UniProt:
  • Canonical: P07711 (Residues: 114-333; Coverage: 70%)
Gene names: CTSL, CTSL1
Pfam: Papain family cysteine protease
Cathepsin L in PDB entry 8a4x, assembly 1, front view.
Cathepsin L in PDB entry 8a4x, assembly 1, side view.
Cathepsin L in PDB entry 8a4x, assembly 1, top view.
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