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Human butyrylcholinesterase in complex with zinc and N,N,N-trimethyl-2-oxo-2-(2-(pyridin-2-ylmethylene)hydrazineyl)ethan-1-aminium

X-ray diffraction
2.53Å resolution
PDB entry 8am1 coloured by chain, front view.
PDB entry 8am1 coloured by chain, side view.
PDB entry 8am1 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cholinesterase
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Multimeric state: monomeric
Accessible surface area: 21696.05 Å2
Buried surface area: 5056.62 Å2
Dissociation area: 122.51 Å2
Dissociation energy (ΔGdiss): 0.32 kcal/mol
Dissociation entropy (TΔSdiss): 0.84 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138982

Macromolecules

Cholinesterase
Chain: A
Length: 529 amino acids
Theoretical weight: 59.71 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P06276 (Residues: 29-557; Coverage: 92%)
Gene names: BCHE, CHE1
Pfam: Carboxylesterase family
Cholinesterase in PDB entry 8am1, assembly 1, front view.
Cholinesterase in PDB entry 8am1, assembly 1, side view.
Cholinesterase in PDB entry 8am1, assembly 1, top view.
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