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Human cathepsin B in complex with the carbamate inhibitor 31

X-ray diffraction
1.7Å resolution
PDB entry 8b5f coloured by chain, front view.
PDB entry 8b5f coloured by chain, side view.
PDB entry 8b5f coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cathepsin B light chain
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Multimeric state: monomeric
Accessible surface area: 11171.89 Å2
Buried surface area: 147.93 Å2
Dissociation area: 73.97 Å2
Dissociation energy (ΔGdiss): -0.55 kcal/mol
Dissociation entropy (TΔSdiss): -0.28 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139795

Macromolecules

Cathepsin B
Chain: A
Length: 255 amino acids
Theoretical weight: 27.96 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P07858 (Residues: 79-333; Coverage: 79%)
Gene names: CPSB, CTSB
Pfam: Papain family cysteine protease
Cathepsin B in PDB entry 8b5f, assembly 1, front view.
Cathepsin B in PDB entry 8b5f, assembly 1, side view.
Cathepsin B in PDB entry 8b5f, assembly 1, top view.
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