› 8bgi

X-ray diffraction
2.56Å resolution

GABA-A receptor a5 homomer - a5V1 - Flumazenil

Released:
DOI: 10.2210/pdb8bgi/pdb
PDB entry 8bgi coloured by chain, front view.
PDB entry 8bgi coloured by chain, side view.
PDB entry 8bgi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The molecular basis of drug selectivity for α5 subunit-containing GABAA receptors.
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
OpenAccess logo Nat Struct Mol Biol (2023)
PMID: 37903907

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-234014 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gamma-aminobutyric acid receptor subunit alpha-5 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 361 amino acids
Theoretical weight: 41.21 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P31644 (Residues: 32-346, 424-450; Coverage: 79%)
Gene name: GABRA5
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand SO4 29 x SO4
Ligand FYP 5 x FYP
Ligand P9N 5 x P9N
Ligand NAG 6 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: C2
Unit cell:
a: 200.769Å b: 131.641Å c: 119.168Å
α: 90° β: 100.19° γ: 90°
R-values:
R R work R free
0.255 0.254 0.277
Expression system: Homo sapiens

Quick links

Citations

1 mention without citation

The molecular basis of drug selectivity for α5 subunit-containing GABAA receptors.
Kasaragod et al. (2023)