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GABA-A receptor a5 homomer - a5V1 - Flumazenil

X-ray diffraction
2.56Å resolution
PDB entry 8bgi coloured by chain, front view.
PDB entry 8bgi coloured by chain, side view.
PDB entry 8bgi coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo pentamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Gamma-aminobutyric acid receptor subunit alpha-5
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Multimeric state: homo pentamer
Accessible surface area: 62336.86 Å2
Buried surface area: 36914.65 Å2
Dissociation area: 15,272.62 Å2
Dissociation energy (ΔGdiss): 230.44 kcal/mol
Dissociation entropy (TΔSdiss): 62.74 kcal/mol
Symmetry number: 5
PDBe Complex ID: PDB-CPX-234014

Macromolecules

Gamma-aminobutyric acid receptor subunit alpha-5
Chains: A, B, C, D, E
Length: 361 amino acids
Theoretical weight: 41.21 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P31644 (Residues: 32-346, 424-450; Coverage: 79%)
Gene name: GABRA5
Pfam:
Gamma-aminobutyric acid receptor subunit alpha-5 in PDB entry 8bgi, assembly 1, front view.
Gamma-aminobutyric acid receptor subunit alpha-5 in PDB entry 8bgi, assembly 1, side view.
Gamma-aminobutyric acid receptor subunit alpha-5 in PDB entry 8bgi, assembly 1, top view.
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