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Tau Paired Helical Filament from Extracellular Vesicles from Alzheimer's disease brain

Electron Microscopy
3.16Å resolution
PDB entry 8bgs coloured by chain, front view.
PDB entry 8bgs coloured by chain, side view.
PDB entry 8bgs coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo heptamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Microtubule-associated protein tau
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Multimeric state: homo heptamer
Accessible surface area: 26045.14 Å2
Buried surface area: 32237.38 Å2
Dissociation area: 987.74 Å2
Dissociation energy (ΔGdiss): -10.77 kcal/mol
Dissociation entropy (TΔSdiss): 13.02 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-216312

Macromolecules

Microtubule-associated protein tau
Chains: A, B, C, D, E, F, r
Length: 441 amino acids
Theoretical weight: 45.92 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P10636 (Residues: 1-758; Coverage: 58%)
  • Best match: P10636-8 (Residues: 1-441)
Gene names: MAPT, MAPTL, MTBT1, TAU
Pfam: Tau and MAP protein, tubulin-binding repeat
Microtubule-associated protein tau in PDB entry 8bgs, assembly 1, front view.
Microtubule-associated protein tau in PDB entry 8bgs, assembly 1, side view.
Microtubule-associated protein tau in PDB entry 8bgs, assembly 1, top view.
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