› 8bgs

Electron Microscopy
3.16Å resolution

Tau Paired Helical Filament from Extracellular Vesicles from Alzheimer's disease brain

Released:
DOI: 10.2210/pdb8bgs/pdb
PDB entry 8bgs coloured by chain, front view.
PDB entry 8bgs coloured by chain, side view.
PDB entry 8bgs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease.
Fowler SL, Behr TS, Turkes E, Cauhy PM, Foiani MS, Schaler A, Crowley G, Bez S, Ficulle E, Tsefou E, O'Brien DP, Fischer R, Geary B, Gaur P, Miller C, D'Acunzo P, Levy E, Duff KE, Ryskeldi-Falcon B
bioRxiv (2023)
PMID: 37163117
Related structures: EMD-16035

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-273151 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated protein tau Chains: A, B, C, D, E, F, r
Molecule details ›
Chains: A, B, C, D, E, F, r
Length: 441 amino acids
Theoretical weight: 45.92 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P10636 (Residues: 1-758; Coverage: 58%)
  • Best match: P10636-8 (Residues: 1-441)
Gene names: MAPT, MAPTL, MTBT1, TAU
Sequence domains: Tau and MAP protein, tubulin-binding repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.16Å
Relevant EMDB volumes: EMD-16035

Quick links

Citations

1 review citation

The Enigma of Tau Protein Aggregation: Mechanistic Insights and Future Challenges.
Zheng et al. (2024)