› 8btb

Electron Microscopy
14Å resolution

Hexameric human IgG3 Fc complex

Released:
DOI: 10.2210/pdb8btb/pdb
PDB entry 8btb coloured by chain, front view.
PDB entry 8btb coloured by chain, side view.
PDB entry 8btb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains.
Abendstein L, Dijkstra DJ, Tjokrodirijo RTN, van Veelen PA, Trouw LA, Hensbergen PJ, Sharp TH
OpenAccess logo Nat Commun 14 4027 (2023)
PMID: 37419978
Related structures: EMD-16227

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-218766 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ig-like domain-containing protein Chains: A, C, E, G, I, K
Molecule details ›
Chains: A, C, E, G, I, K
Length: 209 amino acids
Theoretical weight: 23.77 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NF17 (Residues: 228-436; Coverage: 41%)
Gene name: FLJ00385
Sequence domains: Immunoglobulin C1-set domain
Ig-like domain-containing protein Chains: B, D, F, H, J, L
Molecule details ›
Chains: B, D, F, H, J, L
Length: 209 amino acids
Theoretical weight: 23.78 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NF17 (Residues: 230-438; Coverage: 41%)
Gene name: FLJ00385
Sequence domains: Immunoglobulin C1-set domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 14Å
Relevant EMDB volumes: EMD-16227
Expression system: Homo sapiens

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