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Hexameric human IgG3 Fc complex

Electron Microscopy
14Å resolution
PDB entry 8btb coloured by chain, front view.
PDB entry 8btb coloured by chain, side view.
PDB entry 8btb coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dodecamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: IG-heavy chain
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Multimeric state: hetero dodecamer
Accessible surface area: 104118.72 Å2
Buried surface area: 23305.77 Å2
Dissociation area: 4,067.7 Å2
Dissociation energy (ΔGdiss): -18.47 kcal/mol
Dissociation entropy (TΔSdiss): 73.18 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-218766

Macromolecules

Ig-like domain-containing protein
Chains: A, C, E, G, I, K
Length: 209 amino acids
Theoretical weight: 23.77 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NF17 (Residues: 228-436; Coverage: 41%)
Gene name: FLJ00385
Pfam: Immunoglobulin C1-set domain
Ig-like domain-containing protein in PDB entry 8btb, assembly 1, front view.
Ig-like domain-containing protein in PDB entry 8btb, assembly 1, side view.
Ig-like domain-containing protein in PDB entry 8btb, assembly 1, top view.
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Ig-like domain-containing protein
Chains: B, D, F, H, J, L
Length: 209 amino acids
Theoretical weight: 23.78 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NF17 (Residues: 230-438; Coverage: 41%)
Gene name: FLJ00385
Pfam: Immunoglobulin C1-set domain
Ig-like domain-containing protein in PDB entry 8btb, assembly 1, front view.
Ig-like domain-containing protein in PDB entry 8btb, assembly 1, side view.
Ig-like domain-containing protein in PDB entry 8btb, assembly 1, top view.
Molecule details ›

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