› 8bwi

X-ray diffraction
3.4Å resolution

Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1), crystal form 2

Released:
DOI: 10.2210/pdb8bwi/pdb
PDB entry 8bwi coloured by chain, front view.
PDB entry 8bwi coloured by chain, side view.
PDB entry 8bwi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular mechanism of BMP signal control by Twisted gastrulation.
Malinauskas T, Moore G, Rudolf AF, Eggington H, Belnoue-Davis HL, El Omari K, Griffiths SC, Woolley RE, Duman R, Wagner A, Leedham SJ, Baldock C, Ashe HL, Siebold C
Nat Commun 15 4976 (2024)
PMID: 38862520

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-246098 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Twisted gastrulation protein homolog 1 Chain: A
Molecule details ›
Chain: A
Length: 210 amino acids
Theoretical weight: 23.57 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9GZX9 (Residues: 26-223; Coverage: 100%)
Gene names: PSEC0250, TSG, TWSG1
Sequence domains: Twisted gastrulation (Tsg) protein conserved region

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P6422
Unit cell:
a: 92.25Å b: 92.25Å c: 95.96Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.298 0.296 0.342
Expression system: Homo sapiens

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