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single soak stabilizer for ERa - 14-3-3 interaction (AZ275)

X-ray diffraction
1.2Å resolution
PDB entry 8bz0 coloured by chain, front view.
PDB entry 8bz0 coloured by chain, side view.
PDB entry 8bz0 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Estrogen receptor and 14-3-3 protein sigma
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Multimeric state: hetero tetramer
Accessible surface area: 24070.51 Å2
Buried surface area: 4185.95 Å2
Dissociation area: 1,035.1 Å2
Dissociation energy (ΔGdiss): -1.3 kcal/mol
Dissociation entropy (TΔSdiss): 13.27 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-136921

Macromolecules

14-3-3 protein sigma
Chain: A
Length: 236 amino acids
Theoretical weight: 26.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P31947 (Residues: 1-231; Coverage: 93%)
Gene names: HME1, SFN
Pfam: 14-3-3 protein
14-3-3 protein sigma in PDB entry 8bz0, assembly 1, front view.
14-3-3 protein sigma in PDB entry 8bz0, assembly 1, side view.
14-3-3 protein sigma in PDB entry 8bz0, assembly 1, top view.
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Estrogen receptor
Chain: B
Length: 5 amino acids
Theoretical weight: 614 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P03372 (Residues: 591-595; Coverage: 1%)
Gene names: ESR, ESR1, NR3A1
ERalpha peptide in PDB entry 8bz0, assembly 1, front view.
ERalpha peptide in PDB entry 8bz0, assembly 1, side view.
ERalpha peptide in PDB entry 8bz0, assembly 1, top view.
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