› 8c0w

Electron Microscopy
4.7Å resolution

Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrate in twin seam state

Released:
DOI: 10.2210/pdb8c0w/pdb
PDB entry 8c0w coloured by chain, front view.
PDB entry 8c0w coloured by chain, side view.
PDB entry 8c0w coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrate.
Rüttermann M, Koci M, Lill P, Geladas ED, Kaschani F, Klink BU, Erdmann R, Gatsogiannis C
OpenAccess logo Nat Commun 14 5942 (2023)
PMID: 37741838
Related structures: EMD-16373

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero heptamer (preferred)
PDBe Complex ID:
PDB-CPX-273419 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Peroxisomal ATPase PEX6 Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 1030 amino acids
Theoretical weight: 115.69 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P33760 (Residues: 1-1030; Coverage: 100%)
Gene names: N0310, PAS8, PEX6, YNL329C
Sequence domains:
Peroxisomal ATPase PEX1 Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 823 amino acids
Theoretical weight: 92.76 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P24004 (Residues: 201-1023; Coverage: 79%)
Gene names: PAS1, PEX1, YKL197C
Sequence domains:
unknown peptide Chain: R
Molecule details ›
Chain: R
Length: 9 amino acids
Theoretical weight: 784 Da
Source organism: Saccharomyces cerevisiae

Ligands and Environments

3 bound ligands:
Ligand ATP 10 x ATP
Ligand MG 10 x MG
Ligand ADP 2 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.7Å
Relevant EMDB volumes: EMD-16373
Expression system: Saccharomyces cerevisiae

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