› 8c1y

X-ray diffraction
1.8Å resolution

Small molecule stabilizer for 14-3-3/ChREBP (Cmd 30)

Released:
DOI: 10.2210/pdb8c1y/pdb
PDB entry 8c1y coloured by chain, front view.
PDB entry 8c1y coloured by chain, side view.
PDB entry 8c1y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity.
Katz LS, Visser EJ, Plitzko KF, Pennings M, Cossar PJ, Tse IL, Kaiser M, Brunsveld L, Scott DK, Ottmann C
OpenAccess logo bioRxiv (2024)
PMID: 38405965

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-243756 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
14-3-3 protein sigma Chain: A
Molecule details ›
Chain: A
Length: 236 amino acids
Theoretical weight: 26.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P31947 (Residues: 1-231; Coverage: 93%)
Gene names: HME1, SFN
Sequence domains: 14-3-3 protein
Carbohydrate-responsive element-binding protein Chain: B
Molecule details ›
Chain: B
Length: 18 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9NP71 (Residues: 117-134; Coverage: 2%)
Gene names: BHLHD14, MIO, MLXIPL, WBSCR14

Ligands and Environments

1 bound ligand:
Ligand U0U 1 x U0U
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, DESY BEAMLINE P11
Spacegroup: C2221
Unit cell:
a: 81.626Å b: 111.651Å c: 62.827Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.189 0.223
Expression systems:
  • Escherichia coli
  • Not provided

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