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Small molecule stabilizer for 14-3-3/ChREBP (Cmd 30)

X-ray diffraction
1.8Å resolution
PDB entry 8c1y coloured by chain, front view.
PDB entry 8c1y coloured by chain, side view.
PDB entry 8c1y coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Carbohydrate-responsive element-binding protein and 14-3-3 protein sigma
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Multimeric state: hetero tetramer
Accessible surface area: 24682.46 Å2
Buried surface area: 5992.8 Å2
Dissociation area: 2,003.15 Å2
Dissociation energy (ΔGdiss): -6.36 kcal/mol
Dissociation entropy (TΔSdiss): 18.68 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-243756

Macromolecules

14-3-3 protein sigma
Chain: A
Length: 236 amino acids
Theoretical weight: 26.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P31947 (Residues: 1-231; Coverage: 93%)
Gene names: HME1, SFN
Pfam: 14-3-3 protein
14-3-3 protein sigma in PDB entry 8c1y, assembly 1, front view.
14-3-3 protein sigma in PDB entry 8c1y, assembly 1, side view.
14-3-3 protein sigma in PDB entry 8c1y, assembly 1, top view.
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Carbohydrate-responsive element-binding protein
Chain: B
Length: 18 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9NP71 (Residues: 117-134; Coverage: 2%)
Gene names: BHLHD14, MIO, MLXIPL, WBSCR14
MLX interacting protein like in PDB entry 8c1y, assembly 1, front view.
MLX interacting protein like in PDB entry 8c1y, assembly 1, side view.
MLX interacting protein like in PDB entry 8c1y, assembly 1, top view.
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