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Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2304

Source organism: Homo sapiens
Biochemical function: ATP binding
Biological process: cell surface receptor protein serine/threonine kinase signaling pathway
Cellular component: membrane

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EC 2.7.11.30: Receptor protein serine/threonine kinase

Reaction catalysed:
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Systematic name:
ATP:[receptor-protein] phosphotransferase
Alternative Name(s):
  • Activin receptor kinase
  • Receptor serine/threonine protein kinase
  • Receptor type I serine/threonine protein kinase
  • Receptor type II serine/threonine protein kinase
  • STK13
  • TGF-beta kinase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Activin receptor type-1
The deposited structure of PDB entry 8c7w contains 1 copy of Pfam domain PF00069 (Protein kinase domain) in Activin receptor type-1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Activin receptor type-1
IPR008271
Domain description: Serine/threonine-protein kinase, active site
Occurring in:
  1. Activin receptor type-1
IPR017441
Domain description: Protein kinase, ATP binding site
Occurring in:
  1. Activin receptor type-1
IPR001245
Domain description: Serine-threonine/tyrosine-protein kinase, catalytic domain
Occurring in:
  1. Activin receptor type-1
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Activin receptor type-1
IPR000333
Domain description: Ser/Thr protein kinase, TGFB receptor
Occurring in:
  1. Activin receptor type-1

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