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Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2304

X-ray diffraction
2.26Å resolution
PDB entry 8c7w coloured by chain, front view.
PDB entry 8c7w coloured by chain, side view.
PDB entry 8c7w coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Activin receptor type-1
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Multimeric state: monomeric
Accessible surface area: 14172.39 Å2
Buried surface area: 1736.92 Å2
Dissociation area: 107.59 Å2
Dissociation energy (ΔGdiss): -1.28 kcal/mol
Dissociation entropy (TΔSdiss): -0.27 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170070

Macromolecules

Activin receptor type-1
Chain: A
Length: 301 amino acids
Theoretical weight: 34.54 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q04771 (Residues: 201-499; Coverage: 61%)
Gene names: ACVR1, ACVRLK2
Pfam: Protein kinase domain
InterPro:
Activin receptor type-1 in PDB entry 8c7w, assembly 1, front view.
Activin receptor type-1 in PDB entry 8c7w, assembly 1, side view.
Activin receptor type-1 in PDB entry 8c7w, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q04771  
130120406080100120140160180200220240260280300
 
100200300
UniProt
Q04771
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Secondary structure
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