PDB 8cey biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1 (preferred)

Download 3D Visualisation

Assembly Name: N-glycosylase/DNA lyase
hide full assembly name

Multimeric state: monomeric

Accessible surface area: 14045.46 Å²

Buried surface area: 101.84 Å²

Dissociation area: 50.92 Å²

Dissociation energy (ΔG^diss): 8.29 kcal/mol

Dissociation entropy (TΔS^diss): -0.13 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-126665

$Monomeric assembly 1 of PDB entry 8cey coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of N-glycosylase/DNA lyase;</li> <li class='image_legend_li'>1 copy of ~{N}-(3,3-dimethylcyclobutyl)imidazo[5,1-b][1,3]thiazole-3-carboxamide;</li> <li class='image_legend_li'>1 copy of NICKEL (II) ION;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 8cey coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of N-glycosylase/DNA lyase;</li> <li class='image_legend_li'>1 copy of ~{N}-(3,3-dimethylcyclobutyl)imidazo[5,1-b][1,3]thiazole-3-carboxamide;</li> <li class='image_legend_li'>1 copy of NICKEL (II) ION;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 8cey coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of N-glycosylase/DNA lyase;</li> <li class='image_legend_li'>1 copy of ~{N}-(3,3-dimethylcyclobutyl)imidazo[5,1-b][1,3]thiazole-3-carboxamide;</li> <li class='image_legend_li'>1 copy of NICKEL (II) ION;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Assembly 2

Download 3D Visualisation

Assembly Name: N-glycosylase/DNA lyase
hide full assembly name

Multimeric state: monomeric

Accessible surface area: 14179.53 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-126665

$Monomeric assembly 2 of PDB entry 8cey coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of N-glycosylase/DNA lyase;</li> <li class='image_legend_li'>1 copy of ~{N}-(3,3-dimethylcyclobutyl)imidazo[5,1-b][1,3]thiazole-3-carboxamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 8cey coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of N-glycosylase/DNA lyase;</li> <li class='image_legend_li'>1 copy of ~{N}-(3,3-dimethylcyclobutyl)imidazo[5,1-b][1,3]thiazole-3-carboxamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 8cey coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of N-glycosylase/DNA lyase;</li> <li class='image_legend_li'>1 copy of ~{N}-(3,3-dimethylcyclobutyl)imidazo[5,1-b][1,3]thiazole-3-carboxamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Assembly 3

Download 3D Visualisation

Assembly Name: N-glycosylase/DNA lyase
hide full assembly name

Multimeric state: monomeric

Accessible surface area: 14116.39 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-126665

$Monomeric assembly 3 of PDB entry 8cey coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of N-glycosylase/DNA lyase;</li> <li class='image_legend_li'>1 copy of ~{N}-(3,3-dimethylcyclobutyl)imidazo[5,1-b][1,3]thiazole-3-carboxamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 3 of PDB entry 8cey coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of N-glycosylase/DNA lyase;</li> <li class='image_legend_li'>1 copy of ~{N}-(3,3-dimethylcyclobutyl)imidazo[5,1-b][1,3]thiazole-3-carboxamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 3 of PDB entry 8cey coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of N-glycosylase/DNA lyase;</li> <li class='image_legend_li'>1 copy of ~{N}-(3,3-dimethylcyclobutyl)imidazo[5,1-b][1,3]thiazole-3-carboxamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Macromolecules

N-glycosylase/DNA lyase

Chains: A, B, C
Length: 318 amino acids
Theoretical weight: 35.82 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:

Canonical: O08760 (Residues: 11-325; Coverage: 91%)

Gene name: Ogg1
Pfam:

8-oxoguanine DNA glycosylase, N-terminal domain
HhH-GPD superfamily base excision DNA repair protein

N-glycosylase/DNA lyase in PDB entry 8cey, assembly 1, front view.

N-glycosylase/DNA lyase in PDB entry 8cey, assembly 1, side view.

N-glycosylase/DNA lyase in PDB entry 8cey, assembly 1, top view.

FASTA Sequence


    >pdb|8cey|A B C

GSHMRHRTLSSSPALWASIPCPRSELRLDLVLASGQSFRWKEQSPAHWSGVLADQVWTLTQTEDQLYCTVYRGDDSQVSRPTLEELETLHKYFQLDVSLAQLYSHWASVDSHFQRVAQKFQGVRLLRQDPTECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPNLHALAGPEAETHLRKLGLGYRARYVRASAKAILEEQGGPAWLQQLRVAPYEEAHKALCTLPGVGAKVADCICLMALDKPQAVPVDVHVWQIAHRDYGWHPKTSQAKGPSPLANKELGNFFRNLWGPYAGWAQAVLFSADLRQ

PDBe-KB: UniProt Coverage View: O08760

Molecule details ›

Download

FASTA (Protein chains A, B, C)
Archive mmCIF file
Updated mmCIF file
PDB file
PDB header
PDB file (gz)
PDBML
PDBML (ATOM lines)
PDBML (no atoms)
Structure Factors
SIFTS XML file with residue-level mappings

Search similar proteins

Similar 3D structures (PDBeFold)
Similar sequences

BLAST O08760 (UniProt)

Protein Data Bank in Europe

Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH11233

Quick links

Assemblies

Assembly 1 (preferred)

Assembly 2

Assembly 3

Macromolecules

Search similar proteins

Quick links

PDBe › 8cey › Structure analysis

Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH11233

Quick links

Assemblies

Assembly 1 (preferred)

Assembly 2

Assembly 3

Macromolecules

Search similar proteins

Quick links

8cey › Structure analysis