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Catalytic Core Domain of HIV-1 Integrase (F185K) bound with BI-224436

X-ray diffraction
2.13Å resolution
PDB entry 8ct7 coloured by chain, front view.
PDB entry 8ct7 coloured by chain, side view.
PDB entry 8ct7 coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Capsid protein p24
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Multimeric state: homo dimer
Accessible surface area: 13411.25 Å2
Buried surface area: 4114.23 Å2
Dissociation area: 1,780.11 Å2
Dissociation energy (ΔGdiss): 10.96 kcal/mol
Dissociation entropy (TΔSdiss): 12.4 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-146209

Macromolecules

Integrase
Chain: A
Length: 161 amino acids
Theoretical weight: 17.89 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P12497 (Residues: 1197-1357; Coverage: 11%)
Gene name: gag-pol
Pfam: Integrase core domain
InterPro:
Integrase in PDB entry 8ct7, assembly 1, front view.
Integrase in PDB entry 8ct7, assembly 1, side view.
Integrase in PDB entry 8ct7, assembly 1, top view.
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