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Crystal Structure of 3-oxoacyl-[acyl-carrier-protein] reductase from Mycobacterium smegmatis with bound NAD

Source organism: Klebsiella pneumoniae
Biochemical function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological process: not assigned
Cellular component: not assigned

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EC 1.1.1.100: 3-oxoacyl-[acyl-carrier-protein] reductase

Reaction catalysed:
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH
Systematic name:
(3R)-3-hydroxyacyl-[acyl-carrier-protein]:NADP(+) oxidoreductase
Alternative Name(s):
  • 3-ketoacyl acyl carrier protein reductase
  • 3-oxoacyl-[ACP]reductase
  • Beta-ketoacyl acyl carrier protein (ACP) reductase
  • Beta-ketoacyl reductase
  • Beta-ketoacyl thioester reductase
  • Beta-ketoacyl-ACP reductase
  • Beta-ketoacyl-[acyl-carrier protein](ACP) reductase
  • Beta-ketoacyl-acyl carrier protein reductase
  • NADPH-specific 3-oxoacyl-[acylcarrier protein]reductase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF13561
Domain description: Enoyl-(Acyl carrier protein) reductase
Occurring in:
  1. 3-oxoacyl-[acyl-carrier-protein] reductase
The deposited structure of PDB entry 8cxa contains 4 copies of Pfam domain PF13561 (Enoyl-(Acyl carrier protein) reductase) in 3-oxoacyl-[acyl-carrier-protein] reductase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002347
Domain description: Short-chain dehydrogenase/reductase SDR
Occurring in:
  1. 3-oxoacyl-[acyl-carrier-protein] reductase
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. 3-oxoacyl-[acyl-carrier-protein] reductase

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