› 8d1b

Electron Microscopy
3.57Å resolution

CryoEM structure of human orphan GPCR GPR179 in complex with extracellular matrix protein pikachurin

Released:
DOI: 10.2210/pdb8d1b/pdb
PDB entry 8d1b coloured by chain, front view.
PDB entry 8d1b coloured by chain, side view.
PDB entry 8d1b coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179.
Patil DN, Pantalone S, Cao Y, Laboute T, Novick SJ, Singh S, Savino S, Faravelli S, Magnani F, Griffin PR, Singh AK, Forneris F, Martemyanov KA
Sci Signal 16 eadd9539 (2023)
PMID: 37490546
Related structures: EMD-27121

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-222593 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Pikachurin Chains: C, D
Molecule details ›
Chains: C, D
Length: 234 amino acids
Theoretical weight: 25.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q63HQ2 (Residues: 784-1017; Coverage: 24%)
Gene names: AGRINL, AGRNL, EGFLAM, PIKA
Sequence domains:
Probable G-protein coupled receptor 179 Chains: A, B
Molecule details ›
Chains: A, B
Length: 740 amino acids
Theoretical weight: 81.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6PRD1 (Residues: 1-740; Coverage: 31%)
Gene names: GPR158L, GPR158L1, GPR179
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.57Å
Relevant EMDB volumes: EMD-27121
Expression system: Homo sapiens

Quick links

Citations

1 mention without citation

Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179.
Patil et al. (2023)