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CryoEM structure of human orphan GPCR GPR179 in complex with extracellular matrix protein pikachurin

Electron Microscopy
3.57Å resolution
PDB entry 8d1b coloured by chain, front view.
PDB entry 8d1b coloured by chain, side view.
PDB entry 8d1b coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Probable G-protein coupled receptor 179 and Pikachurin
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Multimeric state: hetero tetramer
Accessible surface area: 39650.24 Å2
Buried surface area: 7142.29 Å2
Dissociation area: 1,530.21 Å2
Dissociation energy (ΔGdiss): -15.95 kcal/mol
Dissociation entropy (TΔSdiss): 25.71 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-222593

Macromolecules

Pikachurin
Chains: C, D
Length: 234 amino acids
Theoretical weight: 25.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q63HQ2 (Residues: 784-1017; Coverage: 24%)
Gene names: AGRINL, AGRNL, EGFLAM, PIKA
Pfam:
Pikachurin in PDB entry 8d1b, assembly 1, front view.
Pikachurin in PDB entry 8d1b, assembly 1, side view.
Pikachurin in PDB entry 8d1b, assembly 1, top view.
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Probable G-protein coupled receptor 179
Chains: A, B
Length: 740 amino acids
Theoretical weight: 81.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6PRD1 (Residues: 1-740; Coverage: 31%)
Gene names: GPR158L, GPR158L1, GPR179
Pfam:
Probable G-protein coupled receptor 179 in PDB entry 8d1b, assembly 1, front view.
Probable G-protein coupled receptor 179 in PDB entry 8d1b, assembly 1, side view.
Probable G-protein coupled receptor 179 in PDB entry 8d1b, assembly 1, top view.
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