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Human Ago2 bound to miR122(21nt) with PIWI loop swapped to AtAgo10 sequence

X-ray diffraction
2.5Å resolution
PDB entry 8d6j coloured by chain, front view.
PDB entry 8d6j coloured by chain, side view.
PDB entry 8d6j coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct RNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protein argonaute-2 and RNA
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Multimeric state: hetero dimer
Accessible surface area: 36983.21 Å2
Buried surface area: 3506.98 Å2
Dissociation area: 1,703.3 Å2
Dissociation energy (ΔGdiss): 37.32 kcal/mol
Dissociation entropy (TΔSdiss): 11.11 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-215257

Macromolecules

Protein argonaute-2
Chain: A
Length: 859 amino acids
Theoretical weight: 97.48 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UKV8 (Residues: 1-859; Coverage: 100%)
Gene names: AGO2, EIF2C2
Pfam:
Protein argonaute-2 in PDB entry 8d6j, assembly 1, front view.
Protein argonaute-2 in PDB entry 8d6j, assembly 1, side view.
Protein argonaute-2 in PDB entry 8d6j, assembly 1, top view.
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RNA chain B
Name: RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3')
Representative chains: B
Source organism: synthetic construct [32630]
Expression system: Not provided
Length: 21 nucleotides
Theoretical weight: 6.79 KDa
RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3') in PDB entry 8d6j, assembly 1, front view.
RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3') in PDB entry 8d6j, assembly 1, side view.
RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3') in PDB entry 8d6j, assembly 1, top view.
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